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Irresistible Spicy Southern Cheesy Chicken Spaghetti Casserole

Creamy, cheesy chicken spaghetti casserole with a Southern kick. Loaded with tender chicken, melted cheese, and just the right amount of spice—perfect for family dinners and potlucks.
Prep Time: 15 minutesCook Time: 35 minutesTotal Time: 50 minutesServings: 6–8Course: DinnerCuisine: Southern / American

Print Recipe
Ingredients Method

Ingredients
  

  • 12 oz 340 g spaghetti, broken in half
  • 2 cups cooked chicken shredded (rotisserie works well)
  • 2 tablespoons butter
  • 1 small onion finely diced
  • 3 cloves garlic minced
  • 8 oz 225 g cream cheese, softened
  • 1 cup heavy cream or whole milk
  • ½ cup chicken broth
  • 1½ cups shredded cheddar cheese
  • 1 cup shredded mozzarella cheese
  • 1 4 oz can diced green chilies
  • ½ teaspoon paprika
  • ¼ –½ teaspoon cayenne pepper to taste
  • ½ teaspoon salt
  • ½ teaspoon black pepper
  • Optional: hot sauce or red pepper flakes

Method
 

  1. Preheat oven to 375°F (190°C). Grease a 9×13-inch baking dish.
  2. Cook spaghetti in salted water until al dente. Drain and set aside.
  3. In a large skillet, melt butter over medium heat. Sauté onion until soft, then add garlic and cook 30 seconds.
  4. Stir in cream cheese, cream, and chicken broth until smooth.
  5. Add cheddar, mozzarella, green chilies, paprika, cayenne, salt, and pepper. Stir until melted.
  6. Fold in cooked chicken and spaghetti until evenly coated.
  7. Transfer to baking dish, top with extra cheese, and bake 25–30 minutes until bubbly and golden.
  8. Rest 5 minutes before serving.